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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPPL2C
All Species:
0.61
Human Site:
S224
Identified Species:
1.67
UniProt:
Q8IUH8
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IUH8
NP_787078.1
684
74503
S224
R
A
R
R
G
G
G
S
G
G
H
H
Q
L
Q
Chimpanzee
Pan troglodytes
XP_523673
684
74537
P224
R
A
R
R
G
G
G
P
G
G
H
H
Q
L
Q
Rhesus Macaque
Macaca mulatta
XP_001115879
684
74573
P224
R
A
R
R
G
G
G
P
G
G
H
R
Q
P
R
Dog
Lupus familis
XP_548046
660
70155
A213
A
R
G
A
G
G
G
A
A
A
P
G
E
A
A
Cat
Felis silvestris
Mouse
Mus musculus
A2A6C4
690
76248
L230
Q
A
Q
R
G
G
G
L
G
G
H
N
Q
Q
Q
Rat
Rattus norvegicus
Q5PQL3
577
63718
R148
D
L
Q
D
I
F
R
R
F
G
H
E
V
M
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507224
648
71872
T214
N
V
T
F
T
P
L
T
V
V
I
F
V
V
I
Chicken
Gallus gallus
Q5F383
596
66378
L167
Y
A
P
N
E
P
V
L
D
Y
N
M
V
I
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782326
512
56836
A83
S
S
L
E
G
R
V
A
A
V
M
R
G
N
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
94.4
70.4
N.A.
69.1
41.5
N.A.
33
45.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
33.3
Protein Similarity:
100
99.1
96.1
78.3
N.A.
80.2
57.5
N.A.
51
60
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
47.5
P-Site Identity:
100
93.3
73.3
20
N.A.
66.6
13.3
N.A.
0
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
93.3
80
33.3
N.A.
86.6
26.6
N.A.
13.3
20
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
56
0
12
0
0
0
23
23
12
0
0
0
12
12
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% C
% Asp:
12
0
0
12
0
0
0
0
12
0
0
0
0
0
0
% D
% Glu:
0
0
0
12
12
0
0
0
0
0
0
12
12
0
0
% E
% Phe:
0
0
0
12
0
12
0
0
12
0
0
12
0
0
0
% F
% Gly:
0
0
12
0
67
56
56
0
45
56
0
12
12
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
56
23
0
0
0
% H
% Ile:
0
0
0
0
12
0
0
0
0
0
12
0
0
12
23
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
12
12
0
0
0
12
23
0
0
0
0
0
23
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
12
12
0
12
0
% M
% Asn:
12
0
0
12
0
0
0
0
0
0
12
12
0
12
0
% N
% Pro:
0
0
12
0
0
23
0
23
0
0
12
0
0
12
0
% P
% Gln:
12
0
23
0
0
0
0
0
0
0
0
0
45
12
34
% Q
% Arg:
34
12
34
45
0
12
12
12
0
0
0
23
0
0
12
% R
% Ser:
12
12
0
0
0
0
0
12
0
0
0
0
0
0
0
% S
% Thr:
0
0
12
0
12
0
0
12
0
0
0
0
0
0
0
% T
% Val:
0
12
0
0
0
0
23
0
12
23
0
0
34
12
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
12
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _